In 1955, couple Betty Hartman and Ted Hardesty are driving down a country road when they come across the seemingly wounded child Jedidiah Sawyer. In an attempt to help him, Betty follows him to a dilapidated barn, where she is promptly killed by his murderous and sadistic family. Her father, Sheriff Hartman, is called to the crime scene, where he is shocked to find his daughter deceased. Despite the efforts of matriarch Verna Sawyer, Hartman responds by taking Jedidiah into custody as retribution against the Sawyers, sending him to a mental institution known as the Gorman House Youth Reformery.

Ten years later at the Gorman House, where inmates are renamed to avoid their dangerous families, nurse Elizabeth White forms a bond with a boy named Jackson.