Struggling New York City graphic novelist John Hollar learns that his mother, Sally is diagnosed with a brain tumor, and joins his brother, Ron, and father, Don, by her side. Her attending physician Dr. Fong tells them that the tumor is scheduled to be removed later that week. John is also facing the birth of his first child with his girlfriend Rebecca. Ron is spying on his ex-wife Stacey, whom he divorced years ago, but he is confronted by her new partner Reverend Dan.

John meets his high school classmate and mother's nurse Jason, who married Gwen, John's ex-fiancée. Jason rightly suspects that Gwen only married him after becoming pregnant with their child, and still has feelings for John.